Browsing by Author "Singh, D."

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A Hybrid Evolutionary-Based MPPT for Photovoltaic Systems under Partial Shading Conditions
(Institute of Electrical and Electronics Engineers Inc., 2020) Joisher, M.; Singh, D.; Taheri, S.; Espinoza-Trejo, D.R.; Pouresmaeil, E.; Taheri, H.
Under partial shading conditions (PSCs), photovoltaic (PV) system characteristics vary and may have multiple power peaks. Conventional maximum power point tracking (MPPT) methods are unable to track the global peak. In addition, it takes a considerable time to reach the maximum power point (MPP). To address these issues, this paper proposes an improved hybrid MPPT method using the conventional evolutional algorithms, i.e., Particle Swarm Optimization (PSO) and Differential Evaluation (DE). The main feature of the proposed hybrid MPPT method is the advantage of one method compensates for shortcomings of the other method. Furthermore, the algorithm is simple and rapid. It can be easily implemented on a low-cost microcontroller. To evaluate the performance of the proposed method, MATLAB simulations are carried out under different PSCc. Experimental verifications are conducted using a boost converter setup, an ET-M53695 panel and a TMS320F28335 DSP. Finally, the simulation and hardware results are compared to those from the PSO and DE methods. The superiority of the hybrid method over PSO and DE methods is highlighted through the results. © 2013 IEEE.
Exploring Plant-Derived Bioactive Compounds in Olea Europaea L. Leaves as Potent Inhibitors of PTP-1B Using an In silico Approach
(World Scientific, 2024) Deshpande, N.S.; Wagh, S.; Sharma, A.P.; Ramesh, A.; Mahindra; Lavanya; Moksha, B.S.; Divyashree; Disha; Dixit, S.R.; Singh, D.; Bidye, D.P.; Revanasiddappa, B.C.
In this study, we focus on exploring the medicinal potential of Olea Europaea L., a commonly used plant with diverse indigenous medicinal applications. The main aim is to identify promising phytoconstituents from Olea Europaea L. leaves that can act as inhibitors for the PTP-1B target, utilizing an in silico approach. The phytoconstituents were sourced from the IMMPAT database, and molecular docking was employed to assess their binding affinities. The docking results revealed that rutin (-10.05 kcal/mol) and quercetin (-8.28 kcal/mol) displayed the highest binding scores against PTP-1B, outperforming reference compounds. Furthermore, MM-GBSA calculations indicated favorable free binding energy. To ensure stability, 200 ns Molecular Dynamics simulations were conducted on the 2QBS-Rutin complex. The results revealed that the 2QBS-Rutin complex showed stable conformation throughout the simulation, maintaining consistency with RMSD values below 1 Å. This study highlights rutin and quercetin as promising phytoconstituents from Olea Europaea L. leaves, demonstrating potent-binding affinities against PTP-1B inhibitors. © 2024 World Scientific Publishing Company.
Synthesis, Molecular Docking, MD Simulation and Evaluation of Anticancer Activity of Novel 1,3,4-Oxadiazole Derivatives against Ehrlich Ascites Carcinoma (EAC) Cell Lines
(World Scientific, 2024) Deshpande, N.S.; Naik, S.; Udayakumar, U.; Prabhu, A.; Rani, V.; Dixit, S.R.; Singh, D.; Revanasiddappa, B.C.
In this study, a new series of 1,3,4-oxadiazole derivatives (3a- 3h) was synthesized, characterized using various analytical techniques (FT-IR, 1H- and 13C-NMR, mass spectrometry), and tested for their effectiveness against Ehrlich's Ascites Carcinoma (EAC) cell lines in vitro. After 48 h of exposure to these test compounds, the EAC cells exhibited a dose-dependent reduction in their viability. Among the tested compounds, 3b and 3e demonstrated the most potent anticancer effects, with IC50 values of 352.69 μM and 177.44 μ M, respectively. Consequently, these compounds were chosen for further investigation into their mechanisms of action on EAC cell lines. The assessment included the induction of apoptosis and the analysis of DNA damage, which were evaluated using fluorescence staining and the comet assay. These assessments revealed distinctive apoptotic characteristics such as nuclear fragmentation, cytoplasmic shrinkage and DNA damage. As a result, these compounds hold promise as potential anticancer agents. The study also delved into the binding affinities of these compounds through molecular docking analysis, and the findings showed that compounds 3b and 3e exhibited a strong binding affinity with the receptor Transforming Growth Factor-Beta Receptor I (TGF-βRI) kinase (PDB ID: 1PY5), surpassing the reference compound 5-fluorouracil. Additionally, calculations related to Molecular Mechanics Generalized Born Surface Area (MM-GBSA) indicated favorable free binding energy. The compounds also displayed acceptable ADMET properties. To validate the stability of the bond between compounds 3b and 3e with the 1PY5 receptor, a molecular dynamics simulation lasting 100 ns was carried out. © 2024 World Scientific Publishing Company.