Browsing by Author "Scheibel, T."

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    Chitosan-based nanocomposites for medical applications
    (John Wiley and Sons Inc, 2021) SelvaKumar, S.; Scheibel, T.
    Chitosan as a biobased polymer is gaining increasing attention due to its extraordinary physico-chemical characteristics and properties. While a primary use of chitosan has been in horticultural and agricultural applications for plant defense and to increase crop yield, recent research reports display various new utilizations in the field of advanced biomedical devices, targeted drug delivery, and as bioimaging sensors. Chitosan possesses multiple characteristics such as antimicrobial properties, stimuli-responsiveness, tunable mechanical strength, biocompatibility, biodegradability, and water-solubility. Further, chitosan can be processed into nanoparticles, nano-vehicles, nanocapsules, scaffolds, fiber meshes, and 3D printed scaffolds for a variety of applications. In recent times, nanoparticles incorporated in chitosan matrices have been identified to show superior biological activity, as cells tend to proliferate/differentiate faster when they interact with nanocomposites rather than bulk or micron size substrates/scaffolds. The present article intents to cover chitosan-based nanocomposites used for regenerative medicine, wound dressings, drug delivery, and biosensing applications. © 2021 The Authors. Journal of Polymer Science published by Wiley Periodicals LLC.
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    Evaluation of piezoelectric behavior and biocompatibility of poly(vinylidene fluoride) ultrafine fibers with incorporated talc nanosheets
    (John Wiley and Sons Inc, 2022) Shetty, S.; SelvaKumar, S.; Salehi, S.; Pellert, A.; Scheibel, M.; Scheibel, T.; Anandhan, S.
    Herein, we fabricated biocompatible ultrafine fibers based on talc nanosheets (TNS)/PVDF composites that can exhibit robust electromechanical responses. Piezoresponse force microscopy (PFM) was extensively used to decode various characteristics, including ferroelectric and piezoelectric coefficients. The 0.5 wt% TNS dispersed ultrafine fibers exhibited well-defined ferroelectric characteristics with an enhanced piezoelectric coefficient (d33) of ≈43.3 pm/V compared to 10 pm/V measured for the pristine PVDF ultrafine fibers. It was observed that the piezoelectric coefficient values strongly depended on the morphology and electroactive phase fraction of the ensuing composite ultrafine fiber. The advantage of a high aspect ratio and surface charges offered by TNS alongside electrospinning augmented the composite ultrafine fiber's piezoelectric response. Further, in-vitro cytotoxicity of the TNS/PVDF composite ultrafine fibers was examined using BALB/3T3 fibroblasts based on ISO Standard 10993-5. Importantly, the new composite fibers showed no cytotoxic response and the exposed fibroblasts showed excellent viability. Thus, these fabricated TNS/PVDF piezoelectric ultrafine fibers are well suited for applications in bioelectronics, especially as flexible wearable electronic devices, including sensors. © 2022 Wiley Periodicals LLC.