Browsing by Author "Parameshwarappa, G."

Now showing 1 - 4 of 4

Synthesis of some biologically active 2,4'-bipyridine-5-carbonitriles carrying the 4-hydroxyphenylthio moiety [Russian Source]
(2009) Karabasanagouda, T.; Adhikari, A.V.; Parameshwarappa, G.
A series of new 4-aryl-2'-[(4-hydroxyphenyl)thio]-6oxo-1,6-dihydro-2,4'-bipyridine-5-car bonitriles (3a-k) and 6-amino-4aryl-2'-[(4-hydroxyphenyl) thio]-2,4'-bipyridine-5-carbonitriles (4a-h) were synthesized from 4-hydroxythiophenol (1). The reaction of 4-hydroxythiophenol with 4-acetyl-2-chloropyridine yielded 1-{2-[(4-hydroxyphenyl)thio]pyridin-4-yl}ethanone (2). Further treatment of 2 with ethyl cyanoacetate in the presence of ammonium acetate with various aromatic aldehydes furnished the compounds 3a-k. On the other hand, condensation of 2 with aromatic aldehydes in the presence of alcoholic malononitrile in ammonium acetate gave compounds 4a-h. The structures of the newly synthesized compounds were established on the basis of their elemental analysis, as well as their IR, 1H- and 13C-NMR and mass spectral data. All the title compounds were subjected to in vitro antibacterial testing against two strains and antifungal screening against two fungi. Some of the compounds showed promising activity. 2009 Copyright (CC) SCS.
Synthesis of some biologically active 2,4'-bipyridine-5-carbonitriles carrying the 4-hydroxyphenylthio moiety; Russian Source
(Serbian Chemical Society, 2009) Karabasanagouda, T.; Vasudeva Adhikari, A.V.; Parameshwarappa, G.
A series of new 4-aryl-2'-[(4-hydroxyphenyl)thio]-6oxo-1,6-dihydro-2,4'-bipyridine-5-car bonitriles (3a-k) and 6-amino-4aryl-2'-[(4-hydroxyphenyl) thio]-2,4'-bipyridine-5-carbonitriles (4a-h) were synthesized from 4-hydroxythiophenol (1). The reaction of 4-hydroxythiophenol with 4-acetyl-2-chloropyridine yielded 1-{2-[(4-hydroxyphenyl)thio]pyridin-4-yl}ethanone (2). Further treatment of 2 with ethyl cyanoacetate in the presence of ammonium acetate with various aromatic aldehydes furnished the compounds 3a-k. On the other hand, condensation of 2 with aromatic aldehydes in the presence of alcoholic malononitrile in ammonium acetate gave compounds 4a-h. The structures of the newly synthesized compounds were established on the basis of their elemental analysis, as well as their IR, 1H- and 13C-NMR and mass spectral data. All the title compounds were subjected to in vitro antibacterial testing against two strains and antifungal screening against two fungi. Some of the compounds showed promising activity. 2009 Copyright (CC) SCS.
Synthesis of some new 2-(4-alkylthiophenoxy)-4-substituted-1, 3-thiazoles as possible anti-inflammatory and antimicrobial agents
(2008) Karabasanagouda, T.; Adhikari, A.V.; Dhanwad, R.; Parameshwarappa, G.
A series of new 2-{[4-(alkylthio)phenoxy]methyl}-4-substituted-1,3- thiazoles 4a-q, 6a-j have been synthesized from ethyl [4-(alkylthio)phenoxy] acetates 1a,b through multi-step reaction sequence. The structures of new compounds have been established on the basis of their elemental analysis and IR, 1H and 13C NMR and mass spectral data. Selected title compounds have been evaluated for anti-inflammatory activity and in vitro antibacterial testing against two pathogenic strains and antifungal screening against two fungi.
Synthesis of some new 2-(4-alkylthiophenoxy)-4-substituted-1, 3-thiazoles as possible anti-inflammatory and antimicrobial agents
(2008) Karabasanagouda, T.; Vasudeva Adhikari, A.V.; Dhanwad, R.; Parameshwarappa, G.
A series of new 2-{[4-(alkylthio)phenoxy]methyl}-4-substituted-1,3- thiazoles 4a-q, 6a-j have been synthesized from ethyl [4-(alkylthio)phenoxy] acetates 1a,b through multi-step reaction sequence. The structures of new compounds have been established on the basis of their elemental analysis and IR, 1H and 13C NMR and mass spectral data. Selected title compounds have been evaluated for anti-inflammatory activity and in vitro antibacterial testing against two pathogenic strains and antifungal screening against two fungi.