Browsing by Author "Narayan, R."

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    Development and preclinical evaluation of microneedle-assisted resveratrol loaded nanostructured lipid carriers for localized delivery to breast cancer therapy
    (Elsevier B.V., 2021) Gadag, S.; Narayan, R.; Nayak, A.S.; Catalina Ardila, D.; Sant, S.; Yogendra, Y.; Garg, S.; Nayak, U.Y.
    Resveratrol (RVT) is one of the potent anticancer phytochemicals which has shown promising potential for breast cancer therapy. However, its short half-life and low bioavailability is a major hurdle in its effective use. In this study, we have developed nanostructured lipid carriers (NLCs) of RVT to enable localized delivery of the drug to the breast tissues using microneedle arrays to improve effectiveness. The NLCs were optimized using the Design of Experiments approach and characterized for their particle size, polydispersity index, zeta potential and entrapment efficiency. The RVT-NLCs delivered using microneedle array 1200 showed a higher permeation of RVT across the skin with lower skin retention compared to pure RVT. Further, RVT-NLCs showed higher anticancer activity on MDA-MB-231 breast cancer cell lines and enhanced internalization compared to pure RVT. Moreover, the RVT-NLCs were found to inhibit the migration of MDA-MB-231 breast cancer cell lines. Preclinical studies in rats showed that RVT-NLCs delivered via microneedles demonstrated a remarkable increase in the Cmax, Tmax and AUC0-inf, and a higher localization in breast tissue compared to pure RVT administered orally. These results suggests that the RVT-NLCs administered by microneedle array system is an effective strategy for the local delivery of RVT for breast cancer therapy. © 2021 Elsevier B.V.
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    Micro-Architectural support for High Availability of NoC-based MP-SoC
    (Institute of Electrical and Electronics Engineers Inc., 2019) Singh, R.; Ranga, S.V.; Patil, S.; Krishna, M.; Mehta, M.; Anoop, M.N.; Nandy, S.K.; Haldar, C.; Narayan, R.; Neumann, F.; Baufreton, P.
    In this paper, we focus on increasing the availability of Multi-Processor System on Chip (MP-SoC) for executing user applications, even when some components of the system are faulty. A Network-on-Chip (NoC) provides high bandwidth communication substrate for the multitude of components/modules in such MP-SoCs. Health of such MP-SoC, and hence its availability, is largely dependent on the health of the NoC. We consider an NoC comprising a bidirectional toroidal mesh interconnection of routers. We use a distributed built-in-self-test to identify faulty communication links. We use information so obtained to determine healthy subsystems that can be made available for executing user applications. This feature is key for enhancing availability of MP-SoCs. We realize this feature as a micro-architectural enhancement in MP-SoC that incurs an insignificant hardware overhead of less than 2%. Latency incurred for analyzing availability of MP-SoC is also insignificant. We functionally validate our proposal by emulating the system on a FPGA device and demonstrate increase in availability of the MP-SoC. © 2019 IEEE.