Browsing by Author "Krishnan, G.S."

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Deep neural learning for automated diagnostic code group prediction using unstructured nursing notes
(2020) Jayasimha, A.; Gangavarapu, T.; Sowmya, Kamath S.; Krishnan, G.S.
Disease prediction, a central problem in clinical care and management, has gained much significance over the last decade. Nursing notes documented by caregivers contain valuable information concerning a patient's state, which can aid in the development of intelligent clinical prediction systems. Moreover, due to the limited adaptation of structured electronic health records in developing countries, the need for disease prediction from such clinical text has garnered substantial interest from the research community. The availability of large, publicly available databases such as MIMIC-III, and advancements in machine and deep learning models with high predictive capabilities have further facilitated research in this direction. In this work, we model the latent knowledge embedded in the unstructured clinical nursing notes, to address the clinical task of disease prediction as a multi-label classification of ICD-9 code groups. We present EnTAGS, which facilitates aggregation of the data in the clinical nursing notes of a patient, by modeling them independent of one another. To handle the sparsity and high dimensionality of clinical nursing notes effectively, our proposed EnTAGS is built on the topics extracted using Non-negative matrix factorization. Furthermore, we explore the applicability of deep learning models for the clinical task of disease prediction, and assess the reliability of the proposed models using standard evaluation metrics. Our experimental evaluation revealed that the proposed approach consistently exceeded the state-of-the-art prediction model by 1.87% in accuracy, 12.68% in AUPRC, and 11.64% in MCC score. � 2020 Association for Computing Machinery.
Dynamic and temporal user profiling for personalized recommenders using heterogeneous data sources
(2017) Krishnan, G.S.; Sowmya, Kamath S.
In modern Web applications, the process of user-profiling provides a way to capture user-specific information, which then serves as a source for designing personalized user experiences. Currently, such information about a particular user is available from multiple online sources/services, like social media applications, professional/social networking sites, location based service providers or even from simple Web-pages. The nature of this data being truly heterogeneous, high in volume and also highly dynamic over time, the problem of collecting these data artifacts from disparate sources, to enable complete user-profiling can be challenging. In this paper, we present an approach to dynamically build a structured user profile, that emphasizes the temporal nature to capture dynamic user behavior. The user profile is compiled from multiple, heterogeneous data sources which capture dynamic user actions over time, to capture changing preferences accurately. Natural language processing techniques, machine learning and concepts of the semantic Web were used for capturing relevant user data and implement the proposed '3D User Profile'. Our technique also supports the representation of the generated user profiles as structured data so that other personalized recommendation systems and Semantic Web/Linked Open Data applications can consume them for providing intelligent, personalized services. � 2017 IEEE.
A Supervised Approach for Patient-Specific ICU Mortality Prediction Using Feature Modeling
(2019) Krishnan, G.S.; Sowmya, Kamath S.
Intensive Care Units (ICUs) are one of the most essential, but expensive healthcare services provided in hospitals. Modern monitoring machines in critical care units continuously generate huge amount of data, which can be used for intelligent decision-making. Prediction of mortality risk of patients is one such predictive analytics application, which can assist hospitals and healthcare personnel in making informed decisions. Traditional scoring systems currently in use are parametric scoring methods which often suffer from low accuracy. In this paper, an empirical study on the effect of feature selection on the feature set of traditional scoring methods for modeling an optimal feature set to represent each patient�s profile along with a supervised learning approach for ICU mortality prediction have been presented. Experimental evaluation of the proposed approach in comparison to standard severity scores like SAPS-II, SOFA and OASIS showed that the proposed model outperformed them by a margin of 12�16% in terms of prediction accuracy. � 2019, Springer Nature Singapore Pte Ltd.
A supervised learning approach for ICU mortality prediction based on unstructured electrocardiogram text reports
(2018) Krishnan, G.S.; Sowmya, Kamath S.
Extracting patient data documented in text-based clinical records into a structured form is a predominantly manual process, both time and cost-intensive. Moreover, structured patient records often fail to effectively capture the nuances of patient-specific observations noted in doctors� unstructured clinical notes and diagnostic reports. Automated techniques that utilize such unstructured text reports for modeling useful clinical information for supporting predictive analytics applications can thus be highly beneficial. In this paper, we propose a neural network based method for predicting mortality risk of ICU patients using unstructured Electrocardiogram (ECG) text reports. Word2Vec word embedding models were adopted for vectorizing and modeling textual features extracted from the patients� reports. An unsupervised data cleansing technique for identification and removal of anomalous data/special cases was designed for optimizing the patient data representation. Further, a neural network model based on Extreme Learning Machine architecture was proposed for mortality prediction. ECG text reports available in the MIMIC-III dataset were used for experimental validation. The proposed model when benchmarked against four standard ICU severity scoring methods, outperformed all by 10�13%, in terms of prediction accuracy. � 2018, Springer International Publishing AG, part of Springer Nature.
TAGS: Towards Automated Classification of Unstructured Clinical Nursing Notes
(2019) Gangavarapu, T.; Jayasimha, A.; Krishnan, G.S.; S, S.K.
Accurate risk management and disease prediction are vital in intensive care units to channel prompt care to patients in critical conditions and aid medical personnel in effective decision making. Clinical nursing notes document subjective assessments and crucial information of a patient�s state, which is mostly lost when transcribed into Electronic Medical Records (EMRs). The Clinical Decision Support Systems (CDSSs) in the existing body of literature are heavily dependent on the structured nature of EMRs. Moreover, works which aim at benchmarking deep learning models are limited. In this paper, we aim at leveraging the underutilized treasure-trove of patient-specific information present in the unstructured clinical nursing notes towards the development of CDSSs. We present a fuzzy token-based similarity approach to aggregate voluminous clinical documentations of a patient. To structure the free-text in the unstructured notes, vector space and coherence-based topic modeling approaches that capture the syntactic and latent semantic information are presented. Furthermore, we utilize the predictive capabilities of deep neural architectures for disease prediction as ICD-9 code group. Experimental validation revealed that the proposed Term weighting of nursing notes AGgregated using Similarity (TAGS) model outperformed the state-of-the-art model by 5% in AUPRC and 1.55% in AUROC. � 2019, Springer Nature Switzerland AG.