Browsing by Author "Isloor, Arun M."

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A Method Of Green Synthesis Of Zwitterionic Polymeric Nanoparticles
(Indian Patent Office, Chennai, 2024-12-30) Isloor, Arun M.; Mendonca, Nidhi Regina
Fabrication and Characterization of Polyphenylsulfone Based Ultrafiltration Hollow Fiber Membranes for Groundwater Treatment Studies
(National Institute of Technology Karnataka, Surathkal, 2022) Kumar, Mithun; Todet, Somasekhara Rao; Isloor, Arun M.
Groundwater is a vital resource that furnishes drinking water to human beings. Liquid and solid wastes, animal wastes, sewage plants, and septic tanks are all main sources of contamination in the groundwater. Furthermore, sewage, industrial effluents, agricultural discharge and residential waste, inorganic pollutants, fertilizer, run-off from urban areas, thermal contaminants, organic compounds, radioactive pollutants and toxic metals all cause a hazard to the groundwater quality. Drinking water is derived from groundwater, which is a valuable natural resource. Drinking water continues to be a significant source of many of the water-borne diseases and death of human beings in the world due to untreated and uncontrolled release of contaminated water to rivers and many other water collecting ponds. Drinking water purification by low-pressure ultrafiltration hollow fiber membrane has become more popular. It replaces many traditional separation technologies due to their high surface area to volume ratio, high packing density, high flux and resistance to chemical degradation. Polyphenylsulfone (PPSU) is a versatile polymer for membrane preparation with high chemical/thermal stability, increased heat resistance, hydrolysis stability and excellent mechanical properties. However, membranes prepared by PPSU as a base polymer are more prone to fouling, hydrophobic and offer less water permeability. In current research work, various inorganic hydrophilic nanoparticles are incorporated into the hydrophobic PPSU membrane matrix to improve hydrophilicity, antifouling and separation efficacy of the fabricated hollow fiber membrane. In present study, the hydrophobic PPSU hollow fiber membranes were fabricated with different dosages of zirconium oxide (ZrO2), zinc–magnesium oxide (ZnO-MgO), aluminum oxide (Al2O3) and polydopamine (PDA) along with constant dosages of cellulose derivatives (cellulose acetate and cellulose acetate phthalate) using non-solvent induced phase separation (NIPS) process. The blended membranes surface morphologies and topologies were analyzed using scanning electron microscopy (SEM) and atomic force microscopy (AFM) respectively. Also studied hydrophilicity, thermal properties and surface charge properties of the fabricated membranes. A cross-flow filtration system was used for analyzing the water permeability, antifouling properties and separation performance of arsenic-V from laboratory prepared arsenic-V solution. The PPSU membranes with 1.5 wt% and 1 wt% of Al2O3 and 3 wt% of cellulose acetate showed improved arsenate oxide removal of 98.67% and 94.89% with permeabilities were 88.41 L/m2h bar and 88.41 L/m2h bar respectively. A 0.6 wt% of ZnO-MgO in CAP/PPSU and 1 wt% of ZnO-MgO in CA/PPSU decontaminated 81.31% and 78.48% with permeabilities of 69.58 L/m2h bar and 198.47 L/m2h bar respectively. Membranes prepared by 1 wt% of ZrO2 in CA/PPSU exhibited arsenic (As-V) rejection of 87.24% with permeabilities of 89.94 L/m2h bar. A 3 wt% of PDA in PPSU/PVP executed enhanced (As-V) removal as 87.15% with flux of 31.80 L/m2h. The modified membranes exhibited enhanced hydrophilicity, antifouling and efficient arsenic-V removal properties.
Fabrication and characterization of polyphenylsulfone-based membranes with nanocomposite additives for water purification application
(National Institute of Technology Karnataka, Surathkal, 2019) Nayak, M Chandra Shekhar; Isloor, Arun M.
Nowadays, membrane separation processes are became as prestigious over other methods towards water purification, due to the low energy consumption and easy to accessible operational conditions. Polyphenylsulfone (PPSU) based membranes are most widely using water purification membrane processes due to its chemical stability, thermal stability, and better mechanical properties. But, one of the major drawback of this polymer is hydrophobicity. In current research, focused to enhance the hydrophilicity as well as the separation efficacy of PPSU membranes with the incorporation of various inorganic hydrophilic nanoparticles. In present work, PPSU based flat-sheet and hollow fiber membranes fabricated with the incorporation of various nanoparticles such as, BiOCl-AC, MWCNTs, ZSM-5, SnO2 and Al2O3-AAC via phase inversion process. The fabricated membranes morphological changes were studied with scanning electron microscopy and atomic force microscopy techniques. The permeability and separation efficacy of membranes was assessed with water, proteins, dyes, heavy metal solutions and different oil/water samples using dead-end and cross-flow filter units. The PPSU membrane with 2 wt. % BiOCl-AC additive exhibited superior performance towards oil/water separation, above 80 % for diesel fuel and above 90 % for crude oil. The PZ-3 type hollow fiber membrane (0.4 wt. % ZSM-5) showed dye rejection performance of 90.81 % for Reactive Black-5 and 82.84 % for Reactive Orange-16. The PCNT-3 membrane (0.3 wt. % MWCNTs) revealed maximum heavy metal ions removal efficacy of 98.13 % for Pb2+, 76.12 % for Hg2+ and 72.92 % for Cd2+ ions, respectively. SnO2 NPs (0.4 wt. %) incorporated hollow fiber membranes (PS-3) were successful in rejection of Reactive Black-5 (RB-5) and Reactive Orange-16 (RO-16) dyes up to 94.44 % and 73.09 % from aqueous solutions. PPSU with alumina doped acid treated activated charcoal incorporated membrane (PA-3) (1 wt. %) displayed above 90 % rejection with BSA and egg albumin (EA) proteins, above 80 % and 70 % rejection with Pb2+ and Cd2+ heavy metals, and in oil-water separation exhibited above 94 % and 87 % rejection with bio-diesel and kerosene oils, respectively.
Preparation and Characterization of Chitosan Based Polymer Membranes for Water Purification Application
(National Institute of Technology Karnataka, Surathkal, 2013) A, Rajesha Kumar; Isloor, Arun M.; Trivedi, Darshak R
For membranes to be competitive with conventional technology, a membrane process needs to operate with a high rate of flux, high degree of selectivity and high resistance to fouling. Chitosan is an excellent membrane material due to its good film forming nature, hydrophilicity, chemical stability and easy chemical modification. The membranes prepared from pure chitosan cannot offer sufficient mechanical stability for application in flow processes. To overcome this problem, techniques of polymer coating and blending have been employed by researchers. Blended chitosan membranes not only display superior mechanical properties but also they are benefited from the intrinsic advantages of each polymer involved in the blend. Chitosan was blended with polysulfone to prepare PSf/CS ultrafiltration membranes. The chemical modification of chitosan has been carried out in the thesis, N-succinyl chitosan (NSCS) and N-propylphosphonyl chitosan (NPPCS) are the two derivatives prepared, among the two, NPPCS is the novel derivative synthesized. Further, these two derivatives were blended with polysulfone to prepare PSf/NSCS and PSf/NPPCS UF membranes. UF membranes were subjected to permeation, antifouling and heavy metal rejection study. Titanium dioxide nanotubes (TiO2NT) were synthesized and incorporated into PSf/CS blend to prepare PSf/CS/TiO2NT UF and NF membranes. PSf/Poly (isobutylene-alt-maleic anhydride) (PIAM) blend nanofiltration membranes were modified by changing coagulation bath with cross-linked chitosan solution. The nanofiltration membranes were subjected to salt rejection study. The PSf/CS, PSf/NSCS and PSf/NPPCS UF membranes showed enhanced permeation and antifouling property compared to pristine PSf UF membrane. Even the UF process was efficient in the rejection of heavy metal ions effectively. Membranes showed a maximum of >90% rejection for Cu, Cd and Ni at very low pressure via polymer enhanced ultrafiltration (PEUF) process. All the nanofiltration membranes showed improved flux and antifouling properties. A maximum of 46 % NaCl rejection was observed in case of PSf/CS/TiO2 membrane with 8 % of nanotube content. Changing the coagulation bath with cross-linked chitosan solution emerged as a best technique to improve salt rejection property of PSf/PIAM membrane.
Preparation and characterization of Polyaniline and TiO2 based nanocomposite membranes for water purification
(National Institute of Technology Karnataka, Surathkal, 2016) Pereira, Valeen Rashmi; Isloor, Arun M.
Membrane based separation has proved its efficiency over other traditional techniques of water purification. Significant research had been done in this area, still the abundant scope of membrane technology has driven many scientists to further explore the field. The current research work is one such attempt to study the efficiency of nanomaterials in the polymeric membranes. This research work is focused on incorporating Polyaniline and TiO2 based nanocomposites into the polymer membranes and to study the properties and performance of the prepared polymer nanocomposite membranes. Polyvinylidene fluoride and Polysulfone were the two polymers used in this study. The different nanomaterials prepared for this study include Polyaniline nanofibers, Polyaniline coated TiO2, sulfated TiO2, Aminated TiO2. The properties and performance of the membranes was analyzed by cross sectional morphology, surface hydrophilicity, water uptake capacity, surface topography studies, permeation properties, antifouling ability. The self-cleaning ability of the membranes was determined by evaluating the flux recovery ratio. The water purification ability of the membranes was evaluated in terms of heavy metal ion rejection and dye removal studies. Polyvinylidene fluoride membrane containing 1.0 wt.% of Polyaniline nanofibers exhibited a maximum rejection of 98.52% and 97.38% for Pb2+ and Cd2+ respectively. Polysulfone membranes containing sulfated TiO2 were successful in removing Methylene Blue dye up to 90.4% under Ultraviolet radiation. PolyanilineTiO2 incorporated Polysulfone hollow fibre membranes showed maximum rejection of 81.5% and 96.5% for Reactive Black 5 and Reactive Orange 16 dyes respectively.
Preparation and Characterization of Polyarylsulfone Based Membranes for Water Purification
(2018) Moideen K, Irfana; Isloor, Arun M.
The membrane technology has gained prominence in water purification because of its energy efficiency. However, the lack of suitable membrane is a major technological hurdle in its acceptance as a primary tool for water purification. The polyarylsulfone based membranes are widely used due to its superior thermal and mechanical stability. However, its poor hydrophilicity and fouling nature have driven further research in this area. Therefore, the present work is an attempt to improve the performance of polyarylsulfone based membranes for water purification. In this research work, the polyarylsulfones such as polysulfone and polyphenylsulfone (PPSU) were used for the fabrication of novel membranes. The performance of membranes was improved by different modification techniques such as blending, chemical modifications, coating, or nanocompositing. The prepared membranes were characterized by analyzing their morphology, topography, surface hydrophilicity, water uptake capacity, and porosity. The membrane performance was further evaluated by the permeability, selectivity, and antifouling studies. The water purification capability of these membranes was studied by the rejection of heavy metal ions, salts, proteins, and dyes present in the aqueous feed. The ultrafiltration flat sheet membranes prepared using hydrophilic modifiers such as sulfonated PPSU, polyethylene glycol-1000, and glycine betaine showed good heavy metal rejection than their pristine counterparts. The studies on the bath composition on sPPSU based membranes also showed to affect the membrane morphology and porosity. The nanoparticles (NP) such as chitosan NPs (CNP), silverloaded CNPs, and MoO3 NPs were prepared and used as additives to fabricate nanocomposite hollow fiber membranes. These modified membranes showed better antifouling and anti-biofouling properties. The thin-film composite nanofiltration membranes were also prepared by incorporating glycine and L-glutamine as hydrophilic additives. The addition of these additives improved the water flux without compromising the salt rejection. Overall, the modified membranes exhibited an enhancement in the hydrophilicity which resulted in the superior antifouling property.
Preparation, characterization and performance studies of polyetherimide based membranes for water purification
(National Institute of Technology Karnataka, Surathkal, 2017) Hebbar, Raghavendra Seetharama; Isloor, Arun M.
Membrane based separation has sustained its efficiency over other traditional techniques of water purification. Significant research has been carried out in this area, still the abundant scope of membrane technology has driven many scientists to further explore the field. The current research work is one such attempt to study the influence of organic and inorganic nanomaterials in the polymeric membranes. This research work is focused on modification of polyetherimide membrane by the addition of organic and inorganic additives to improve the physiochemical properties and its performance. The various additives employed in this work includes citric acid, ascorbic acid, activated bentonite, poly (4-styrenesulfonate) modified bentonite, polydopamine coated HNTs, amine functionalized HNTs, poly(m-aminophenol) coated HNTs and carboxylated Fe2O3 nanoparticles. The properties and performance of the membranes was analyzed by cross sectional morphology, surface hydrophilicity, water uptake capacity, porosity, surface topography studies, permeation properties and antifouling ability. The self-cleaning ability of the membranes was determined by evaluating the flux recovery ratio. The water purification ability of the membranes was assessed in terms of hazardous heavy metal ion rejection, humic acid removal and dye removal applications. The PEI membrane with 4 wt. % activated bentonite dosage showed maximum rejection of 69.3 %, 76.2 % and 82.5 % for 250 ppm of Cd (II), Ni (II) and Cu (II) ion solutions respectively. The 3 wt. % polydopamine modified HNTs in the membrane showed resistance to microbial growth with FRR of 74.5 % and reversible fouling ratio of 60.7 %. The membrane comprising of bentonite clay bearing the poly (4-styrenesulfonate) brushes showed 80.5 % (Pb2+) and 74.6 % (Cd2+) respectively, during PEUF. The hollow fiber membrane with 2 wt. % of poly (maminophenol) coated HNTs exhibited the water flux of 104.9 Lm-1h-1 and only 9.6 % of irreversible fouling with more than 90.3 % of flux recovery. These membranes also showed rejection of 97 % and 94 % for the hazardous reactive red 102 and reactive black 5 dyes respectively.
Preparation, Characterization and Performance Study of New Polysulfone Based Nanofiltration Membranes for Water Filtration
(National Institute of Technology Karnataka, Surathkal, 2013) Padaki, Mahesh S.; Isloor, Arun M.
Nanofiltration (NF) is a membrane based liquid separation technology which displays separation characteristics in the intermediate range between Reverse Osmosis (RO) and Ultrafiltratiom (UF). RO is capable of producing very clean water and high concentrate rejection. UF may be used for removal of suspended solids and large organic molecules. Most of the membranes were prepared from organic polymers. Inorganic polymers tend to be expensive. Cellulose derivatives, polysulfone, polyamides polyvinyldifloride are presently available polymers which are being extensively used for membrane preparation. For membranes to be competitive with conventional technology, a membrane process needs to operate with a high rate of flux, high degree of selectivity and high resistance to fouling. There are three main areas of interest when it comes to improving membrane performance: the synthesis process, post-synthesis modification and application process. These three processes were focused and discussed in present work. Synthesis of polymers, chemical modification of polymers and surface modification of the membranes were performed and discussed in this thesis. Polysulfonylaminobenzamide (PSAB), methylated polysulfonylaminobenzamide (mPSAB), poly[(4-aminophenyl)sulfonyl]butanediamide (PASB) and methylated poly[(4-aminopheonyl)sulfonyl]butanediamide (mPASB) were synthesized. Chitosan (CS) was modified into N-Phthaloyl chitosan (NCS) and polysulfone (PSf) was modified into sulfonated polysulfone (sPSf). These polymers were blend with polysulfone for the preparation of NF membranes. Surface modification was mainly carried out by chemical modification, physical vapor deposition and beam irradiation. The general properties of prepared membranes fall in UF and NF regime. The properties varied depending on the nature of the polymer, the functional group present in the polymer and manufacturing process. It was shown that the novel polymers and polymer modification enhanced the performance of the membrane.
Studies on Composite Polyphenylsulfone Membranes for Protein Rejection Applications
(National Institute of Technology Karnataka, Surathkal, 2023) H R, Panchami; Isloor, Arun M.
Wastewater production is unavoidable because it is an inherent component of the value chain in all sectors of life. Faced with water constraints, the global community seeks to investigate all methods for decreasing the over exploitation of finite freshwater resources. Membrane technology has become the preferred approach for reclaiming water from various wastewater sources. Among commercially available polymeric membranes, polyphenylsulfone (PPSU)-based membranes play a vital role as they exhibit excellent thermal and mechanical stability, high chemical resistance, impact resistance and hydrolytic stability. However, PPSU-based membranes are hydrophobic, causing poor antifouling ability in aqueous phase separation urge polyphenylsulfone membrane for future development. This research work focused on modifications of polyphenylsulfone membranes by adding polymeric, inorganic and organic-inorganic additives to improve the physicochemical properties and their performances. The various additives employed in this study includes zwitterionic polymeric nanoparticles, polymeric microspheres, Ag-doped zinc oxide, PANI-bentonite nanocomposite, HKUST-1 metal-organic framework and AgI/UiO-66(NH2) metal-organic frameworks. All these additives are synthesized and are hydrophilic. The as-fabricated composite or nanocomposite membranes were completely characterized using analytical techniques. The PPSU membrane with 1.0 wt.% PANI-bentonite nanohybrid membrane showed the highest BSA rejection rate was 96.7% and egg albumin was 95.2% and HKUST-1 MOF of 1.0 wt.% membrane showed the highest pepsin rejection was 79.5%. The highest flux recovery ratio (FRR) was 85.2% showed by the 1.0 wt.% of polymeric microspheres incorporated membrane. The PPSU membrane with 1.0 wt.% of HKUST-1 showed the highest pure water permeability (198.12 Lm-2h-1bar-1). The 1.0 wt.% membrane showed the lowest contact angle and the highest hydrophilicity due to the addition of zwitterionic polymeric nanoparticles. All the as-synthesized composite additive materials not only increased hydrophilicity but also altered the membrane surface charge feasible for protein rejection.
Synthesis and Characterization of Some Hydrophilic Polysulfone Based Membranes and their Application for Sustainable Water Purification
(National Institute of Technology Karnataka, Surathkal, 2020) Ibrahim, G P Syed.; Isloor, Arun M.
The intensifying obligation to clean, freshwater and declining obtainability from natural resources, water need to be conserved effectually to come across future requirements. This deteriorating condition fascinated the attention of global researchers towards nonconventional sources, such as ocean water, treated water and groundwater. Membrane separation processes have been established briskly in the past decade into the leading technology for effective water treatment. Among the commercially available polymeric membranes, polysulfone based membranes play an important role as it exhibits improved chemical, thermal and mechanical stability. However, the trade-off between permeability and solute rejection, reduced surface hydrophilicity and higher propensity towards fouling of polysulfone membranes urge further development. In this research work, polysulfone membrane performance was improved by incorporating hydrophilic polymeric nanoparticles and blending with hydrophilic polymers. The as-prepared composite or nanocomposite membranes were thoroughly characterized using analytical techniques. The nanocomposite hollow fiber ultrafiltration membranes were prepared with surface modified halloysite nanotubes, zwitterionic polymer nanoparticles and zwitterionically modified Fe3O4 demonstrated improved antifouling ability and dye rejection with higher permeability compared to the pristine membrane. The as-added nanoparticles not only increased the membrane surface porosity but also altered the surface hydrophilicity and charge. The polysulfone blend ultrafiltration membrane was fabricated, which exhibited enhanced heavy metal ions such as Pb2+ (91.5 %) and Cd2+ (72.3 %) rejection. To further improve the heavy metal rejection, thin-film composite/nanocomposite membranes were prepared. The as-prepared nanofiltration membranes demonstrated higher rejection of heavy metal ions such as Pb2+ (>98%) and Cd2+ (>95 %) and improved antifouling property.
Synthesis of Some New Pyrazole Derivatives and Their Antituberculosis Screening
(National Institute of Technology Karnataka, Surathkal, 2017) Nandam, Harikrishna; Isloor, Arun M.
Antibiotics improve the better living life in the world for human as well as animals. Many types of bacteria are dramatically reduces illnesses and deaths caused by various infections. Therefore, it occupies great importance to discover newer, effective and safer drugs in the modern world. In the last few decades, the process of drug discovery program has undergone fundamental transformation to synthesize customs molecules and new chemical entities (NCEs). Organic synthesis approaches towards designing, innovation and low molecular chemical structures, which are easily available, biologically active, will definitely aid in combating the ailments prevailing universally. Although, the increasing cost for discovery of such molecules in terms of research and development, analysis, in vitro and in vivo studies for new sites were worries the pharmaceutical research. Newer heterocyclic compounds are being employed constantly in the hope of striking a proper perspective in combating the pathogen bacterial infections. A systemic investigation of this class of heterocyclic lead revealed that, pyrazole and its derivatives are well known nitrogen containing heterocyclic compounds occupy an important role in medicinal chemistry with wide variety of biological properties. Owing to this therapeutic degree of pyrazole and its derivatives, in the current research work, it has been planned to find out various potent heterocyclic moieties with pyrazole through active functional systems to form a new molecular framework. Accordingly, different libraries of pyrazole based compounds comprising of thiazole (T1-12), pyrazoline (T13-27), 1,4-dihydropyridine (T28-45), 1,3,4-oxadiazole (T46-54), [1,2,4]triazolo[3,4-b] [1,3,4]thiadiazole (T55-63), benzimidazole (T64-79) and trifluoromethylbenzyloxy derivatives (T80-97) have been designed and synthesized. Newly synthesized chemical derivatives were confirmed by various spectroscopic techniques viz. FT-IR, 1H-NMR, 13C-NMR, LC-MS and elemental analyses. Additionally, three dimension structures of few molecules were confirmed by single crystal X-ray diffraction (S-XRD) studies. Further, the target compounds were subjected to screen preliminary in vitro antitubercular, antibacterial and antifungal activities. The active molecules were identified and tested for their cytotoxicity studies against non-cancerous cells.
Synthesis, biological studies of some new trifluoromethyl and halogen substituted quinoline derivatives
(National Institute of Technology Karnataka, Surathkal, 2014) B, Garudachari; Isloor, Arun M.; Satyanarayan, M. N.
The heterocyclic chemistry is one of the most important and complex branches of organic chemistry, which provides variety of biologically important compounds. The most recent innovative improvements and developments in health technologies, includes success in the discovery and production of new drugs. In recent years, the mounting threat of bacterial resistance has heightened the urgency to discover and develop anti-ineffective agents with novel mechanism of action and enhanced activity profile. Quinoline nucleus is an important class of heterocyclic compounds found in many synthetic and natural products with a wide range of pharmacological activities. Quinolone derivatives have significant tissue penetration property and inhibit the DNA synthesis by forming complex with DNA gyrase or topoisomerase II enzyme. Prompted by the biological significance of quinoline and with the aim of finding new trifluoromethylquinoline derivatives having enhanced antimicrobial activity, in the present research work it was planned to synthesize some new quinoline derivatives. Based on the literature survey five series of quinoline derivatives were planned and synthesized. The synthetic and purification methods have been optimized for the new derivatives. Characterizations of newly synthesized compounds were successfully done by means of spectral methods like IR, 1H-NMR, 13C-NMR, mass spectral and elemental analysis. Three dimensional structures of some derivatives were evidenced by X-ray crystallographic study. All the newly synthesized compounds were tested for their invitro antimicrobial activity. Some of the synthesized compounds were found to exhibit potent activity. A combination of trifluoromethylquinoline with certain substituents has caused an enhanced antimicrobial activity. Hence they are ideally suited for further modifications to obtain more efficient antimicrobial agents.
Synthesis, Characterization and Biological Studies of Some New N-Bridged Heterocycles
(National Institute of Technology Karnataka, Surathkal, 2013) Malladi, Shridhar Ashok; Isloor, Arun M.
Antibiotics, first introduced in the 1940s, dramatically reduced illnesses and deaths caused by bacterial infections. Before the introduction of antibiotics, infectious diseases claimed countless victims. But a hallmark of antibiotics is that they lose their effectiveness over time as bacteria naturally evolve and mutate and so become resistant to the medicine's effects. The rate of growth of antimicrobial resistance has accelerated due to the widespread global use of antibiotics. It is important to find out newer, safer and more effective antibiotics with broad-spectrum of activity. Heterocyclic compounds by virtue of their specific activity could be employed in the treatment of infectious diseases. A systematic investigation of this class of heterocyclic lead revealed that pyrazole containing pharmacoactive agents play important role in medicinal chemistry. The prevalence of pyrazole cores in biologically active molecules has stimulated the need for elegant and efficient ways to make these heterocyclic lead. Owing to the pharmacological importance of pyrazole and its derivatives, in the present work, it has been contemplated to couple various biologically active heterocyclic moieties with pyrazole through active functional systems to form a new molecular framework. Accordingly, different series, viz. triazolothiadiazole (P1-10), oxadiazole (P11-24), thiazole (P25-38), Schiff base (P39-48), Cyanopyridone (P49-63) and pyrazoline derivatives (P64-74) carrying pyrazole ring as core structure have been designed and synthesized. Structures of the newly synthesized compounds were confirmed by FT-IR, 1H NMR, 13C NMR, mass spectral studies followed by elemental analyses. The newly synthesized compounds were tested for their antimicrobial activity. Selected compounds were also screened for anti-inflammatory and antioxidant activity. Some of the synthesized compounds were found to exhibit potent activity. The acute oral toxicity study for few of the biologically active compounds was also performed. Molecular docking studies of selected compounds were carried out for better understanding of the drug-receptor interaction.