Browsing by Author "Deshmukh, P."

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    Design, synthesis, in-vitro evaluation and molecular docking studies of novel indole derivatives as inhibitors of SIRT1 and SIRT2
    (Academic Press Inc. apjcs@harcourt.com, 2019) Manjula, R.; Gokhale, N.; Unni, S.; Deshmukh, P.; Reddyrajula, R.; Srinivas-Bharath, M.M.; Udayakumar, U.; Padmanabhan, B.
    Sirtuins (SIRTs), class III HDAC (Histone deacetylase) family proteins, are associated with cancer, diabetes, and other age-related disorders. SIRT1 and SIRT2 are established therapeutic drug targets by regulating its function either by activators or inhibitors. Compounds containing indole moiety are potential lead molecules inhibiting SIRT1 and SIRT2 activity. In the current study, we have successfully synthesized 22 indole derivatives in association with an additional triazole moiety that provide better anchoring of the ligands in the binding cavity of SIRT1 and SIRT2. In-vitro binding and deacetylation assays were carried out to characterize their inhibitory effects against SIRT1 and SIRT2. We found four derivatives, 6l, 6m, 6n, and 6o to be specific for SIRT1 inhibition; three derivatives, 6a, 6d and 6k, specific for SIRT2 inhibition; and two derivatives, 6s and 6t, which inhibit both SIRT1 and SIRT2. In-silico validation for the selected compounds was carried out to study the nature of binding of the ligands with the neighboring residues in the binding site of SIRT1. These derivatives open up newer avenues to explore specific inhibitors of SIRT1 and SIRT2 with therapeutic implications for human diseases. © 2019 Elsevier Inc.
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    Indium antimonide (InSb) waveguide based THz sensor
    (2015) Ranjana, J.S.; Bhatt, P.; Deshmukh, P.; Sangala, B.R.; Satyanarayan, M.N.; Umesh, G.; Prabhu, S.S.
    We demonstrate the sensing capability of InSb based planar THz waveguide with stubs, which can sense biomolecules of a few micro liter quantity in de-ionized (DI) water. We chose Bovine Serum Albumin (BSA), a well-known standard protein molecule to investigate the sensing property. The calculated absorption coefficient from the Fourier transformed transmission characteristics show prominent changes with different concentrations of BSA, demonstrating the potential application of the device to function as a simple THz sensor. � 2015 IEEE.
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    Indium antimonide (InSb) waveguide based THz sensor
    (Institute of Electrical and Electronics Engineers Inc., 2015) Ranjana, J.S.; Bhatt, P.; Deshmukh, P.; Sangala, B.R.; Satyanarayan, M.N.; Umesh, G.; Prabhu, S.S.
    We demonstrate the sensing capability of InSb based planar THz waveguide with stubs, which can sense biomolecules of a few micro liter quantity in de-ionized (DI) water. We chose Bovine Serum Albumin (BSA), a well-known standard protein molecule to investigate the sensing property. The calculated absorption coefficient from the Fourier transformed transmission characteristics show prominent changes with different concentrations of BSA, demonstrating the potential application of the device to function as a simple THz sensor. © 2015 IEEE.
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    Resonant Terahertz InSb Waveguide Device for Sensing Polymers
    (Springer New York LLC barbara.b.bertram@gsk.com, 2016) Shourie, S.R.J.; Bhatt, P.; Deshmukh, P.; Sangala, B.R.; Satyanarayan, M.N.; Umesh, G.; Prabhu, S.S.
    We have demonstrated the possibility of employing a device, designed to operate at terahertz (THz) frequencies, for sensing materials. The device consists of a waveguide section with a pair of stubs located at the middle and oriented transversely to the waveguide axis. The two stubs function as a resonator and, hence, the device would behave as a filter in the THz domain. The device was fabricated by laser micromachining of InSb pellets and was characterized by THz time-domain transmission spectroscopy. For a waveguide width of 740 ?m and stub length of 990 ?m, a transmission minimum is seen to occur at 0.265 THz. We investigated the capability of the device to sense polystyrene, dissolved in toluene, loaded into the stubs. The consequent change in the refractive index in the stubs alters the transmitted signal intensity. Our results show that, a change in concentration of polystyrene even by 1 mol/L, leads to measurable change in the transmission coefficient close to the resonant frequency of the device. Thus, our device operating at THz frequencies shows promising potential as chemical and bio sensors. © 2016, Springer Science+Business Media New York.