Browsing by Author "Chaudhury, K."

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Influence of disjoining pressure on the dynamics of steadily moving long bubbles inside narrow cylindrical capillaries
(2014) Chaudhury, K.; Acharya, P.V.; Chakraborty, S.
We study the influence of disjoining pressure for moving long bubbles inside cylindrical capillaries. Towards that end, consistent thin-film equations, for the annular region separating the bubble from the channel surface, are presented with specific emphasis on three different attributes: (a) the van der Waals interaction, formalized by the classical Lifshitz form of disjoining pressure; (b) the nonuniformity in film thickness, accommodated by the necessary corrections in the disjoining pressure; and (c) the electrostatic component of disjoining pressure, reminiscent of the electrostatic interactions in the presence of surface charges. The present thin-film analysis appositely uncovers the existence and the breakdown of the two-thirds power law for minimum film thickness behavior. This is attributed to the alteration in the characteristic length scales governing the underlying physics, as quantitatively established by our consistent scaling analysis. In the breakdown regimes, the characteristic length scales are found to be composed of the suitable combinations of the capillary number and the physics driven intrinsic length scales. The characteristics of the breakdown regime reported by us appear to match excellently with reported experimental data in the low capillary number regime. Towards unveiling the possible implications of slope and curvature dependence of disjoining pressure, our analysis reveals that the consequent correction term endorses an order two-thirds power of the capillary number contribution without alerting the governing length scales. The subsequent asymptotic analysis reveals that this correction may be neglected to the leading order approximation. Finally, we consider the electrostatic component of the disjoining pressure which may be realized in the presence of surface charges. Our analysis reveals that the significance of the electrostatic interaction is realized over a very small capillary number regime, leading towards the departure from the two-thirds power law type behavior. Reasonably good agreement is obtained with reported experimental data over this regime. 2014 American Physical Society.
Influence of disjoining pressure on the dynamics of steadily moving long bubbles inside narrow cylindrical capillaries
(American Physical Society, 2014) Chaudhury, K.; Acharya, P.V.; Chakraborty, S.
We study the influence of disjoining pressure for moving long bubbles inside cylindrical capillaries. Towards that end, consistent thin-film equations, for the annular region separating the bubble from the channel surface, are presented with specific emphasis on three different attributes: (a) the van der Waals interaction, formalized by the classical Lifshitz form of disjoining pressure; (b) the nonuniformity in film thickness, accommodated by the necessary corrections in the disjoining pressure; and (c) the electrostatic component of disjoining pressure, reminiscent of the electrostatic interactions in the presence of surface charges. The present thin-film analysis appositely uncovers the existence and the breakdown of the two-thirds power law for minimum film thickness behavior. This is attributed to the alteration in the characteristic length scales governing the underlying physics, as quantitatively established by our consistent scaling analysis. In the breakdown regimes, the characteristic length scales are found to be composed of the suitable combinations of the capillary number and the physics driven intrinsic length scales. The characteristics of the breakdown regime reported by us appear to match excellently with reported experimental data in the low capillary number regime. Towards unveiling the possible implications of slope and curvature dependence of disjoining pressure, our analysis reveals that the consequent correction term endorses an order two-thirds power of the capillary number contribution without alerting the governing length scales. The subsequent asymptotic analysis reveals that this correction may be neglected to the leading order approximation. Finally, we consider the electrostatic component of the disjoining pressure which may be realized in the presence of surface charges. Our analysis reveals that the significance of the electrostatic interaction is realized over a very small capillary number regime, leading towards the departure from the two-thirds power law type behavior. Reasonably good agreement is obtained with reported experimental data over this regime. © 2014 American Physical Society.
Metabolomic profiling of doxycycline treatment in chronic obstructive pulmonary disease
(2017) Singh, B.; Jana, S.K.; Ghosh, N.; Das, S.K.; Joshi, M.; Bhattacharyya, P.; Chaudhury, K.
Serum metabolic profiling can identify the metabolites responsible for discrimination between doxycycline treated and untreated chronic obstructive pulmonary disease (COPD) and explain the possible effect of doxycycline in improving the disease conditions. 1H nuclear magnetic resonance (NMR)-based metabolomics was used to obtain serum metabolic profiles of 60 add-on doxycycline treated COPD patients and 40 patients receiving standard therapy. The acquired data were analyzed using multivariate principal component analysis (PCA), partial least-squares-discriminant analysis (PLS-DA), and orthogonal projection to latent structure with discriminant analysis (OPLS-DA). A clear metabolic differentiation was apparent between the pre and post doxycycline treated group. The distinguishing metabolites lactate and fatty acids were significantly down-regulated and formate, citrate, imidazole and L-arginine upregulated. Lactate and folate are further validated biochemically. Metabolic changes, such as decreased lactate level, inhibited arginase activity and lowered fatty acid level observed in COPD patients in response to add-on doxycycline treatment, reflect the anti-inflammatory action of the drug. Doxycycline as a possible therapeutic option for COPD seems promising. 2016 Elsevier B.V.
Metabolomic profiling of doxycycline treatment in chronic obstructive pulmonary disease
(Elsevier B.V., 2017) Singh, B.; Jana, S.K.; Ghosh, N.; Das, S.K.; Joshi, M.; Bhattacharyya, P.; Chaudhury, K.
Serum metabolic profiling can identify the metabolites responsible for discrimination between doxycycline treated and untreated chronic obstructive pulmonary disease (COPD) and explain the possible effect of doxycycline in improving the disease conditions. 1H nuclear magnetic resonance (NMR)-based metabolomics was used to obtain serum metabolic profiles of 60 add-on doxycycline treated COPD patients and 40 patients receiving standard therapy. The acquired data were analyzed using multivariate principal component analysis (PCA), partial least-squares-discriminant analysis (PLS-DA), and orthogonal projection to latent structure with discriminant analysis (OPLS-DA). A clear metabolic differentiation was apparent between the pre and post doxycycline treated group. The distinguishing metabolites lactate and fatty acids were significantly down-regulated and formate, citrate, imidazole and L-arginine upregulated. Lactate and folate are further validated biochemically. Metabolic changes, such as decreased lactate level, inhibited arginase activity and lowered fatty acid level observed in COPD patients in response to add-on doxycycline treatment, reflect the anti-inflammatory action of the drug. Doxycycline as a possible therapeutic option for COPD seems promising. © 2016 Elsevier B.V.