Browsing by Author "Bhattacharya, B."

Now showing 1 - 4 of 4

Design, synthesis and docking studies of quinoline-oxazolidinone hybrid molecules and their antitubercular properties
(2011) Thomas, K.D.; Adhikari, A.V.; Chowdhury, I.H.; Sandeep, T.; Mahmood, R.; Bhattacharya, B.; Sumesh, E.
New series of quinoline-oxazolidinone hybrid molecules were synthesized based on the preliminary docking studies. All the newly synthesized compounds were characterized by spectral analyses. The newly synthesized compounds were screened for their antimycobacterial properties based on the promising preliminary antibacterial screening results. Amongst tested compounds, compounds 8a, 8j and 13a were active at 0.65 ?g/mL against Mycobacterium tuberculosis H 37Rv strain. The mode of action of these active compounds was carried out by docking of receptor enoyl-ACP reductase with newly synthesized candidate ligands 8a, 8j and 13a. These compounds exhibited well established bonds with one or more amino acids in the receptor active pocket. From the docking studies, compound 8j was considered to be the best inhibitor. 2011 Elsevier Masson SAS. All rights reserved.
Design, synthesis and docking studies of quinoline-oxazolidinone hybrid molecules and their antitubercular properties
(2011) Thomas, K.D.; Vasudeva Adhikari, A.V.; Chowdhury, I.H.; Sandeep, T.; Mahmood, R.; Bhattacharya, B.; Sumesh, E.
New series of quinoline-oxazolidinone hybrid molecules were synthesized based on the preliminary docking studies. All the newly synthesized compounds were characterized by spectral analyses. The newly synthesized compounds were screened for their antimycobacterial properties based on the promising preliminary antibacterial screening results. Amongst tested compounds, compounds 8a, 8j and 13a were active at 0.65 ?g/mL against Mycobacterium tuberculosis H 37Rv strain. The mode of action of these active compounds was carried out by docking of receptor enoyl-ACP reductase with newly synthesized candidate ligands 8a, 8j and 13a. These compounds exhibited well established bonds with one or more amino acids in the receptor active pocket. From the docking studies, compound 8j was considered to be the best inhibitor. © 2011 Elsevier Masson SAS. All rights reserved.
Synthesis and Characterization of High-Dielectric-Constant Nanographite Polyurethane Composite
(2018) Mishra, P.; Bhat, B.R.; Bhattacharya, B.; Mehra, R.M.
In the face of ever-growing demand for capacitors and energy storage devices, development of high-dielectric-constant materials is of paramount importance. Among various dielectric materials available, polymer dielectrics are preferred for their good processability. We report herein synthesis and characterization of nanographite polyurethane composite with high dielectric constant. Nanographite showed good dispersibility in the polyurethane matrix. The thermosetting nature of polyurethane gives the composite the ability to withstand higher temperature without melting. The resultant composite was studied for its dielectric constant (?) as a function of frequency. The composite exhibited logarithmic variation of ? from ~ 3000 at 100 Hz to ~ 225 at 60 kHz. The material also exhibited stable dissipation factor (tan ?) across the applied frequencies, suggesting its ability to resist current leakage. 2018, The Minerals, Metals & Materials Society.
Synthesis and Characterization of High-Dielectric-Constant Nanographite–Polyurethane Composite
(Minerals, Metals and Materials Society 184 Thorn Hill Road Warrendale PA 15086, 2018) Mishra, P.; Badekai Ramachandra, B.R.; Bhattacharya, B.; Mehra, R.M.
In the face of ever-growing demand for capacitors and energy storage devices, development of high-dielectric-constant materials is of paramount importance. Among various dielectric materials available, polymer dielectrics are preferred for their good processability. We report herein synthesis and characterization of nanographite–polyurethane composite with high dielectric constant. Nanographite showed good dispersibility in the polyurethane matrix. The thermosetting nature of polyurethane gives the composite the ability to withstand higher temperature without melting. The resultant composite was studied for its dielectric constant (?) as a function of frequency. The composite exhibited logarithmic variation of ? from ~ 3000 at 100 Hz to ~ 225 at 60 kHz. The material also exhibited stable dissipation factor (tan ?) across the applied frequencies, suggesting its ability to resist current leakage. © 2018, The Minerals, Metals & Materials Society.