Browsing by Author "Arulmoli, T."

Now showing 1 - 12 of 12

2-(4-Chloroanilino)-1-(4-chlorophenyl)ethanone
(2011) Fun, H.-K.; Quah, C.K.; Vijesh, A.M.; Isloor, A.M.; Arulmoli, T.
In the title compound, C14H11Cl2NO, the benzene rings form a dihedral angle of 3.14 (6) . Overall, the molecule is close to being planar (r.m.s. deviation for all the non-H atoms = 0.054 ). No significant directional intermolecular interactions are observed in the crystal structure.
2-(4-Chloroanilino)-1-(4-chlorophenyl)ethanone
(2011) Fun, H.-K.; Ching Kheng, C.K.; Vijesh, A.M.; Isloor, A.M.; Arulmoli, T.
In the title compound, C14H11Cl2NO, the benzene rings form a dihedral angle of 3.14 (6)°. Overall, the molecule is close to being planar (r.m.s. deviation for all the non-H atoms = 0.054 Å). No significant directional intermolecular interactions are observed in the crystal structure.
2-(4-Chlorophenyl)-2-oxoethyl 3,4-dimethoxybenzoate
(2011) Fun, H.-K.; Quah, C.K.; Vijesh, A.M.; Isloor, A.M.; Arulmoli, T.
In the title compound, C17H15ClO5, the benzene rings forms a dihedral angle of 74.45 (10) . In the crystal, molecules are linked into C(13) chains along [011] via C-H?O hydrogen bonds. The crystal packing also features short Cl?Cl contacts of 3.1253 (10) ..
2-(4-Chlorophenyl)-2-oxoethyl 3,4-dimethoxybenzoate
(2011) Fun, H.-K.; Ching Kheng, C.K.; Vijesh, A.M.; Isloor, A.M.; Arulmoli, T.
In the title compound, C17H15ClO5, the benzene rings forms a dihedral angle of 74.45 (10)°. In the crystal, molecules are linked into C(13) chains along [011] via C-H?O hydrogen bonds. The crystal packing also features short Cl?Cl contacts of 3.1253 (10) Å..
Diethyl 4-[5-(biphenyl-4-yl)-1H-pyrazol-4-yl]-2,6-dimethyl-1,4-dihydro- pyridine-3,5-dicarboxyl-ate ethanol monosolvate
(2011) Fun, H.-K.; Hemamalini, M.; Vijesh, A.M.; Isloor, A.M.; Arulmoli, T.
In the title compound, C 28H 29N 3O 4 C 2H 6O, the benzene ring makes dihedral angles of 33.72 (13) and 32.86 (13) , respectively, with the adjacent pyrazole and phenyl rings. In the crystal, the components are connected via inter-molecular N - H?O, N - H?N, O - H?O and C - H?O hydrogen bonds, forming a layer parallel to the bc plane. Fun et al. 2011.
Diethyl 4-[5-(biphenyl-4-yl)-1H-pyrazol-4-yl]-2,6-dimethyl-1,4-dihydro- pyridine-3,5-dicarboxyl-ate ethanol monosolvate
(2011) Fun, H.-K.; Hemamalini, M.; Vijesh, A.M.; Isloor, A.M.; Arulmoli, T.
In the title compound, C 28H 29N 3O 4·C 2H 6O, the benzene ring makes dihedral angles of 33.72 (13) and 32.86 (13)°, respectively, with the adjacent pyrazole and phenyl rings. In the crystal, the components are connected via inter-molecular N - H?O, N - H?N, O - H?O and C - H?O hydrogen bonds, forming a layer parallel to the bc plane. © Fun et al. 2011.
Hantzsch reaction: Synthesis and characterization of some new 1,4-dihydropyridine derivatives as potent antimicrobial and antioxidant agents
(2011) Vijesh, A.M.; Isloor, A.M.; Peethambar, S.K.; Shivananda, K.N.; Arulmoli, T.; Isloor, N.A.
In the present study two new series of Hantzsch 1,4-dihydropyridine derivatives (1,4-DHPs) containing substituted pyrazole moiety (4a-f and 5a-f) were synthesized by the reaction of 3-aryl-1H-pyrazole-4-carbaldehydes with 1,3-dicarbonylcompounds (ethylacetoacetate and methylacetoacetate) and ammonium acetate. The newly synthesized compounds were characterized by IR, NMR, mass spectral study and also by C, H, N analyses. New compounds were screened for their antimicrobial activity by well plate method (zone of inhibition). Antioxidant studies of the synthesized compounds were also performed by measuring the DPPH radical scavenging assay. Compounds 4c, 4e and 4f were found to be potent antibacterial and antioxidant agents. The acute oral toxicity study for the compounds 4c, 4e and 4f were carried out and the experimental studies revealed that compounds 4c and 4e is safe up to 3000 mg/kg and no death of animals were recorded. However in compound 4f, we found mortality above 2000 mg and also significant behavioral changes in experimental animals. 2011 Elsevier Masson SAS. All rights reserved.
Hantzsch reaction: Synthesis and characterization of some new 1,4-dihydropyridine derivatives as potent antimicrobial and antioxidant agents
(2011) Vijesh, A.M.; Isloor, A.M.; Peethambar, S.K.; Shivananda, K.N.; Arulmoli, T.; Isloor, N.
In the present study two new series of Hantzsch 1,4-dihydropyridine derivatives (1,4-DHPs) containing substituted pyrazole moiety (4a-f and 5a-f) were synthesized by the reaction of 3-aryl-1H-pyrazole-4-carbaldehydes with 1,3-dicarbonylcompounds (ethylacetoacetate and methylacetoacetate) and ammonium acetate. The newly synthesized compounds were characterized by IR, NMR, mass spectral study and also by C, H, N analyses. New compounds were screened for their antimicrobial activity by well plate method (zone of inhibition). Antioxidant studies of the synthesized compounds were also performed by measuring the DPPH radical scavenging assay. Compounds 4c, 4e and 4f were found to be potent antibacterial and antioxidant agents. The acute oral toxicity study for the compounds 4c, 4e and 4f were carried out and the experimental studies revealed that compounds 4c and 4e is safe up to 3000 mg/kg and no death of animals were recorded. However in compound 4f, we found mortality above 2000 mg and also significant behavioral changes in experimental animals. © 2011 Elsevier Masson SAS. All rights reserved.
Molecular docking studies of some new imidazole derivatives for antimicrobial properties
(2013) Vijesh, A.M.; Isloor, A.M.; Telkar, S.; Arulmoli, T.; Fun, H.-K.
In modern drug designing, molecular docking is routinely used for understanding drug-receptor interaction. In the present study six imidazole derivatives containing substituted pyrazole moiety (2a,. b and 4a-d) were synthesized. Structures of the newly synthesized compounds were characterized by spectral studies. Compounds were screened for their antibacterial activity. Compound 4c was found to be potent antimicrobial against Pseudomonas aeruginosa at concentrations of 1 and 0.5. mg/mL compared to standard drug Streptomycin. All the compounds were subjected to molecular docking studies for the inhibition of the enzyme l-glutamine: d-fructose-6-phosphate amidotransferase [GlcN-6-P] (EC 2.6.1.16). The in silico molecular docking study results showed that, all the synthesized compounds having minimum binding energy and have good affinity toward the active pocket, thus, they may be considered as good inhibitor of GlcN-6-P synthase. 2011.
Molecular docking studies of some new imidazole derivatives for antimicrobial properties
(2013) Vijesh, A.M.; Isloor, A.M.; Telkar, S.; Arulmoli, T.; Fun, H.-K.
In modern drug designing, molecular docking is routinely used for understanding drug-receptor interaction. In the present study six imidazole derivatives containing substituted pyrazole moiety (2a,. b and 4a-d) were synthesized. Structures of the newly synthesized compounds were characterized by spectral studies. Compounds were screened for their antibacterial activity. Compound 4c was found to be potent antimicrobial against Pseudomonas aeruginosa at concentrations of 1 and 0.5. mg/mL compared to standard drug Streptomycin. All the compounds were subjected to molecular docking studies for the inhibition of the enzyme l-glutamine: d-fructose-6-phosphate amidotransferase [GlcN-6-P] (EC 2.6.1.16). The in silico molecular docking study results showed that, all the synthesized compounds having minimum binding energy and have good affinity toward the active pocket, thus, they may be considered as good inhibitor of GlcN-6-P synthase. © 2011.
Synthesis of some new pyrazolone derivatives as potent antimicrobial agents
(2011) Vijesh, A.M.; Isloor, A.M.; Isloor, S.; Shivananda, K.N.; Shyma, P.C.; Arulmoli, T.
Invasive microbial infections are major problems around the world, especially in immuno compromised patients. The recent expansion of antimicrobial drug research has occurred because there is a critical need for new antimicrobial agents to treat these life threatening invasive infections. In the present study three series of new substituted pyrazolone derivatives (5a-f, 6a-f and 8a,b) were synthesized by the Knoevenagel condensation reaction of pyrazolones (3a,b) with various substituted carbaldehydes (4a-f, 7). These newly synthesized compounds were characterized by IR, NMR, mass spectra and also by C, H, N analyses. New compounds were screened for their antimicrobial studies against S. aureus, B. subtilis, E. coli and P. aeruginosa. The results revealed that compounds 5c and 6c having 2,5-dichlorothiophene substituent showed significant antibacterial activity against all tested microorganisms as compared to the standard drug Ceftriaxone.
Synthesis of some new pyrazolone derivatives as potent antimicrobial agents
(2011) Vijesh, A.M.; Isloor, A.M.; Isloor, S.; Shivananda, K.N.; Shyma, P.C.; Arulmoli, T.
Invasive microbial infections are major problems around the world, especially in immuno compromised patients. The recent expansion of antimicrobial drug research has occurred because there is a critical need for new antimicrobial agents to treat these life threatening invasive infections. In the present study three series of new substituted pyrazolone derivatives (5a-f, 6a-f and 8a,b) were synthesized by the Knoevenagel condensation reaction of pyrazolones (3a,b) with various substituted carbaldehydes (4a-f, 7). These newly synthesized compounds were characterized by IR, NMR, mass spectra and also by C, H, N analyses. New compounds were screened for their antimicrobial studies against S. aureus, B. subtilis, E. coli and P. aeruginosa. The results revealed that compounds 5c and 6c having 2,5-dichlorothiophene substituent showed significant antibacterial activity against all tested microorganisms as compared to the standard drug Ceftriaxone.